Table 1 The possible effects of endocrine disrupting chemicals on obesity in the review studies
From: Endocrine disrupting chemicals and obesity prevention: scoping review
First author, year | Study design, sample size | Analysis, exposure | Outcome assessment | Conclusions |
|---|---|---|---|---|
Ribeiro et al. [59] | Systematic Review, Meta-analysis including 73 studies on (mostly cross-sectional design) | Addressing an association of EDCs and anthropometric measures of obesity/body fat | EDCs (BPA, phthalates, parabens) and obesity level or body fat | BPA and phthalates associated with general and abdominal obesity |
Lee et al. [42] | Systematic Review, Meta-analysis including 22 longitudinal and 17 cross-sectional studies | Analyses of prenatal and postnatal EDCs exposure association with growth disturbances | EDCs (phthalate) exposure and body mass index (BMI) and fat mass | Prenatal phthalate exposure associated with low BMI, but not with body fat mass |
[33] | Meta-analysis including 16 studies (12 cross-sectional, 2 case–control, 1 prospective study) | Risk evaluation of T2DM and BPA | Urine and serum EDCs (BPA), T2DM | BPA exposure positively associated with T2DM risk in humans |
[20] | Meta-analysis including 99 studies (17 cohort, 15 cross-sectional, 3 case–control studies) | Association analyses between EDCs and cardiometabolic risk factors | EDCs (phthalates), obesity level in children and adolescents | A positive association between phthalate and some cardiometabolic risk factors |
[69] | Systematic review of cross-sectional (n = 17) and cohort studies (n = 18) were identified that reported on associations between pollutants and obesity measures | Association analyses between EDCs and obesity | EDCs (BPA, others) and obesity in human subjects | A positive association between pollutants, especially BPA, and obesity in humans |
[75] | A systematic review and meta-analysis of the current literature to explore the effects of phthalate exposure on obesity | Association analyses between EDCs (phthalates) and obesity | EDCs (phthalates) and obesity in children and adults | The associations exist between phthalate exposure and obesity in children and adults |
Maqbool et al. [48] | A systematic review of environmental toxicants and possible involved mechanisms | The interactions and mechanism of toxicity in relation to human general health problems | EDC risks for human by targeting different organs and systems in the body | The association between endocrine disruptions and human diseases |
[19] | A systematic literature search of the association of prenatal phthalate exposure with an absolute adiposity marker | Association analyses between EDCs (prenatal exposure) and obesity | EDCs (prenatal phthalates exposure) and obesity development | A weak relationship between phthalate exposure and children's obesity trajectory in a sex-specific manner |
Andújar et al. [3] | A literature review of the available research in humans, in in vivo and in vitro tests | Association EDCs of and analogues and the associated health effects | EDCs (BPA, BPA analogues) and obesogenic effects | BPA analogues may have an impact on human health, especially in terms of obesity and other adverse health effects in children |
Gutiérrez-Torres et al.,[25] | A systematic review from 16 cohort studies were identified and reviewed | Association between prenatal exposure to EDCs in preschoolers | EDCs (BPA, phthalates) impact on the anthropometric variables and biochemical parameters | EDCs is positively associated with cardiometabolic risk factors |