Research trajectory of the mechanism of preeclampsia: a scientometric perspective

Table 11 The clusters of the keywords

Cluster ID	Cluster name	Size	Silhouette	Mean (years)	Top 5 terms(LSI)
#0	Hypertensive disorders of pregnancy	229	0.62	2010	Preterm birth; gestational hypertension; cardiovascular risk; placental abruption; cerebrovascular risk \| fetal growth restriction
#1	Invasion	223	0.581	2010	Preeclampsia; trophoblast; lncrna tug1; mmp9; mir-204-5p \| trophoblast invasion
#2	Blood pressure	202	0.704	1997	Preeclampsia; hypertension; proteinuria; astragaloside iv; nrf2/ho-1 \| nitric oxide
#3	Angiogenic factors	115	0.723	2011	Nitric oxide; vascular smooth muscle; endothelial growth; transforming growth factor; chronic kidney \| endothelial dysfunction
#4	Oxidative stress	110	0.729	2003	Oxidative stress; air pollution; newborn diseases; vcam-1; animal models \| preeclampsia
#5	Antiphospholipid syndrome	71	0.822	2007	Antiphospholipid syndrome; intrauterine growth restriction; pregnancy loss; obstetric antiphospholipid syndrome; fetal death \| maternal–fetal interface
#6	Systemic hemodynamics	9	0.994	2010	Renal circulation; angiogenic growth factors; systemic hemodynamics; nitric oxide; arterial compliance \| renal circulation

This table highlights major research themes in preeclampsia studies, categorized into keyword clusters based on their frequency and relevance. The largest cluster, #0 Hypertensive disorders of pregnancy (229 studies, mean year 2010), focuses on gestational hypertension, preterm birth, and fetal growth restriction. #1 Invasion (223 studies, mean year 2010) explores mechanisms like trophoblast invasion and non-coding RNAs. #2 Blood pressure (202 studies, mean year 1997) emphasizes hypertension, proteinuria, and oxidative stress pathways. #3 Angiogenic factors (115 studies, the mean year 2011) discusses endothelial dysfunction and nitric oxide pathways, while #4 Oxidative stress (110 studies, the mean year 2003) examines air pollution and animal models. Smaller but more significant clusters include #5 Antiphospholipid syndrome (71 studies, the mean year 2007), focusing on pregnancy loss and maternal–fetal interface, and #6 Systemic hemodynamics (9 studies, the mean year 2010), highlighting renal circulation and arterial compliance. These clusters reflect the diversity and evolution of research priorities in preeclampsia

ISSN: 2072-1315