Research trajectory of the mechanism of preeclampsia: a scientometric perspective

Table 13 Top 25 Keywords with the Strongest Citation Bursts

Keywords	Years	Strength	Begin	End
Preeclampsia	1991	20.87	1991	2004
Release	1991	10.65	1991	2005
Pregnancy induced hypertension	1992	33.6	1992	2005
Prostacyclin	1992	13.48	1992	2005
Endothelial cell	1993	19.4	1993	2008
Plasma	1993	16.68	1993	2005
Intrauterine growth retardation	1993	11.44	1993	2010
Tumor necrosis factor	1995	15.53	1995	2011
Blood pressure	1991	10.52	1995	2001
Nitric oxide	1996	9.17	1996	2013
Lipid peroxidation	1998	11.06	1998	2015
Normal pregnancy	1991	14.78	2002	2012
Nitric oxide synthase	2001	11.48	2003	2011
Necrosis factor alpha	2001	13.7	2006	2015
Endothelial growth factor	1999	12.91	2006	2015
Circulating angiogenic factor	2007	14.29	2007	2015
Soluble endoglin	2007	10.85	2009	2015
Uterine artery doppler	2007	9.34	2010	2013
Agonistic autoantibody	2011	11.48	2011	2016
Proliferation	2012	9.17	2019	2020
Trophoblast cell	2007	12.65	2020	2024
Impact	2018	10.47	2021	2024
Extracellular vesicle	2017	9.47	2021	2024
Circular rna	2020	9.26	2021	2024
Pathophysiology	2010	18.87	2022	2024

This table highlights the top 25 keywords in preeclampsia research that exhibited the most robust citation bursts, reflecting periods of heightened research focus. "Pregnancy-induced hypertension" shows the highest burst strength (33.6) from 1992 to 2005, indicating its centrality during that period. "Preeclampsia" (strength 20.87) and "Endothelial cell" (strength 19.4) also demonstrate sustained influence, reflecting their importance in understanding the pathophysiology. Emerging terms like "Extracellular vesicle" (2017–2024) and "Circular RNA" (2020–2024) highlight modern research directions focusing on molecular and cellular mechanisms. This table provides insights into evolving priorities and emerging trends in preeclampsia research over time

ISSN: 2072-1315