Research trajectory of the mechanism of preeclampsia: a scientometric perspective

Table 15 The clusters of the co-cited references

Cluster ID	Cluster name	Size	Silhouette	Mean (years)	Top 5 terms(LSI)
#0	Hypertensive disorder	269	0.786	2017	Preeclampsia; correlation; gestational diabetes mellitus; influencing factors; genotypic analysis
#1	Angiotensin ii type	194	0.886	2010	Preeclampsia; key enzymes; methionine-homocysteine metabolism; levels; later risk
#2	Potential role	179	0.929	2004	Preeclampsia; prediction; risk factors; plasma; cultured placental explants soluble flt-1 isoforms
#3	Trophoblast cell	151	0.939	2018	Preeclampsia; trophoblast cell invasion; kcnj16 signaling pathway; lncrna xist; trophoblast-derived extracellular vesicles
#4	Hypoxia-inducible transcription factor	132	0.905	1996	Preeclampsia; animal models; lessons; arterial pressure; vascular mechanisms
#5	Fetal growth restriction	108	0.919	2018	Preeclampsia; early biomarkers; novel blood test; animal models; cystathionine gamma-lyase
#6	Bewo cell	99	0.935	2004	Preeclampsia; child health; human development workshop; national institute; executive summary
#7	Transcriptional profile	77	0.912	2010	Preeclampsia; transcriptional profile; decidua; channel expression; pregnancy-mediated adaptation
#8	Endothelial function	76	0.991	1989	Pregnancy; thromboxane; arterial contractile responses; indomethacin-sensitive contracting factor; endothelium-derived relaxing factor
#9	Hypertensive pregnancy	71	0.96	2013	Preeclampsia; pathogenesis; new developments; hypertension; shared disease mechanisms

This table categorizes co-cited references into clusters, each representing a key theme in preeclampsia research. The largest cluster, #0 Hypertensive disorder (269 references, mean year 2017), focuses on gestational diabetes, genotypic analysis, and influencing factors. #1 Angiotensin II type (194 references, mean year 2010) explores enzymatic pathways, metabolism, and later risk factors. #3 Trophoblast cell (151 references, the mean year 2018) emphasizes cell invasion, signalling pathways, and extracellular vesicles, reflecting cutting-edge molecular research. Historical perspectives are captured in clusters like #4 Hypoxia-inducible transcription factor (132 references, the mean year 1996) and #8 Endothelial function (76 references, the mean year 1989), focusing on vascular mechanisms and endothelial responses. Emerging topics, such as #5 Fetal growth restriction and #6 BeWo cell, highlight the search for biomarkers and developmental health insights. These clusters demonstrate the evolution of research priorities from foundational studies to modern advancements in preeclampsia

ISSN: 2072-1315