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Table 5 Association between AUC-OGTT patterns and adverse pregnancy outcomes in different preconception BMI groups

From: Association between the glucose pattern in oral glucose tolerance test and adverse pregnancy outcomes among non-diabetic women

Preconception BMI

SA pattern

(n = 7,834)

MA pattern

(n = 7,894)

P-value

LA pattern

(n = 7,849)

P-value

Normal-weight (n = 16,487)

     

 Preeclampsia

Reference

1.09 (0.78, 1.51)

0.620

1.09 (0.79, 1.51)

0.614

 Preterm birth

Reference

1.09 (0.90, 1.31)

0.393

1.12 (0.93, 1.35)

0.232

 Macrosomia

Reference

1.37 (1.14, 1.65)

0.001

1.67 (1.39, 1.99)

< 0.001

 Caesarean

Reference

1.05 (0.97, 1.14)

0.256

1.13 (1.04, 1.23)

0.004

Underweight (n = 4,730)

     

 Preeclampsia

Reference

3.25 (1.33, 7.96)

0.010

2.65 (1.03, 6.80)

0.043

 Preterm birth

Reference

1.04 (0.74, 1.47)

0.816

1.32 (0.92, 1.87)

0.128

 Macrosomia

Reference

1.77 (1.17, 2.70)

0.008

1.80 (1.16, 2.78)

0.008

 Caesarean

Reference

1.08 (0.93, 1.26)

0.306

1.03 (0.88, 1.22)

0.716

Overweight and Obese (n = 2,360)

     

 Preeclampsia

Reference

0.78 (0.42, 1.45)

0.434

1.49 (0.86, 2.58)

0.153

 Preterm birth

Reference

1.22 (0.68, 2.19)

0.505

1.69 (0.97, 2.94)

0.062

 Macrosomia

Reference

0.91 (0.59, 1.38)

0.644

1.66 (1.13, 2.44)

0.011

 Caesarean

Reference

1.24 (0.99, 1.56)

0.066

1.20 (0.96, 1.51)

0.113

  1. Values are reported as relative risks (95% CIs), and the relative risks were adjusted for maternal age, preconception BMI, ethnicity, smoking history, drinking history, education, gestational weight gain, gravidity, parity, IVF, history of abortion, and history of preterm birth. The SA, MA, and LA patterns represent three distinct categories based on the AUC of OGTT, corresponding to small, medium, and large areas respectively
  2. AUC, area under the curve; OGTT, oral glucose tolerance test; BMI: body mass index; CI, confidence interval; IVF, in vitro fertilization